Facilities and Capabilities

Advanced Electron Microscopy Facility

Advanced Electron Microscopy Core Facility
Gordon Center for Integrated Science
929 E. 57th St.
Rooms: ESB07, ESB23 (Scope room)
Chicago, IL 60637

Technical contact:
Jotham (Joe) Austin
773-702-9091

https://tomocryo.uchicago.edu/

The Advanced Electron Microscopy Facility develops techniques for preserving cellular structure with the highest degree of reliability. These techniques involve different methods for rapidly freezing our samples in order to halt structural and biochemical activity in a very short timeframe, thus preserving structure in the "live" state. Once the sample is preserved in the "live" state, it is then possible to study the ultrastructure of these samples using not only basic Electron Microscopy imaging techniques, but also state-of the-art techniques such as: 1) 3-D electron tomography, and 2) immuno-cytochemistry.

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Advanced Photon Source (APS)

Argonne National Laboratory
9700 South Cass Avenue
Advanced Photon Source
Building 401
Lemont, IL 60439 USA

630-252-9090

https://www1.aps.anl.gov/

The APS provides ultra-bright, high-energy storage ring-generated x-ray beams for research in almost all scientific disciplines. These x-rays allow scientists to pursue new knowledge about the structure and function of materials in the center of the Earth, in outer space, and all points in between. The knowledge gained from this research is impacting the evolution of combustion engines and microcircuits, aiding in the development of new pharmaceuticals, and pioneering nanotechnologies whose scale is measured in billionths of a meter, to name just a few examples.

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Argonne Leadership Computing Facility (ALCF)

Argonne National Laboratory
9700 South Cass Avenue
Building 240
Argonne, IL 60439

http://www.alcf.anl.gov/

The Argonne Leadership Computing Facility’s (ALCF) mission is to accelerate major scientific discoveries and engineering breakthroughs for humanity by designing and providing world-leading computing facilities in partnership with the computational science community.

We help researchers solve some of the world’s largest and most complex problems with our unique combination of supercomputing resources and expertise. ALCF projects cover many scientific disciplines, ranging from chemistry and biology to physics and materials science. Our facility is available to any researcher in the world with a large-scale computing problem through allocations programs supported by DOE and Argonne.

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Cell Screening Core

Cellular Screening Center (CSC)
The University of Chicago
Gordon Center for Integrative Sciences
Room WSB03
929 E. 57th St.
Chicago, IL 60637
773-702-5698

Technical contact:
Siquan Chen
773-256-9772

http://www.igsb.anl.gov/services/csc/

The Cellular Screening Center (CSC) provides high throughput cell and non cell based screening for researchers throughout Chicago area. Both small molecules and siRNA libraries are offered for such screens.

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Center for Nanoscale Materials (CNM)

Center for Nanoscale Materials
Argonne National Laboratory
9700 South Cass Avenue
Building 440
Argonne, IL 60439 USA

http://www.anl.gov/cnm/center-nanoscale-materials

The CNM is a premier user facility providing expertise, instrumentation, and infrastructure for interdisciplinary nanoscience and nanotechnology research. Academic, industrial, and international researchers can access the center through its user program for both nonproprietary and proprietary research. The center's goal is to perform basic research and instrumentation development that explores ways to tailor nanoscale interactions by creating, visualizing, and assembling hybrid nanomaterial architectures for energy-related research and development programs.

The NanoBio Interfaces Group within the CNM might be of particular interest to Microbiome Center members. Its key capabilities include synthesis and self-assembly of nanoparticles; bioconjugation and peptide synthesis, transmission electron microscopy (JEOL JEM-2100F); field emission scanning electron microscopy (JEOL JSM7500F); electron paramagnetic resonance spectroscopy; and laser scanning confocal microscopy (Zeiss LSM 510 Meta).

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Center for Research Informatics

University of Chicago
Knapp Center for Biomedical Discovery
900 E. 57th St.
Chicago, IL 60637

Technical contact:
Sam Volchenboum
773-702-4303

http://cri.uchicago.edu/

We offer state-of-the-art technologies for working with research data—from acquisition and storage to analysis and sharing. Our resources are secure, standards-compliant, and open to all members of the BSD. We collaborate with scientists through all stages of their projects, handling clinical, translational, and basic science data with the highest level of efficiency and security.

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Electron Microscopy Center

Center for Nanoscale Materials
Argonne National Laboratory
9700 South Cass Avenue
Building 440
Argonne, IL 60439 USA

Technical contact:
Dean Miller
630-252-4108

http://www.anl.gov/cnm/group/electron-microscopy-center

The Electron Microscopy Center Group (EMC) develops and maintains unique capabilities for electron beam characterization and applies those capabilities to solve materials challenges. EMC emphasizes three major areas: materials research, experimental technique and instrumentation development, and operation of unique and state-of-the-art instrumentation. One of EMC's signature capabilities is a chromatic-aberration corrected transmission electron microscope, one of only three such instruments currently operating worldwide. State-of-the-art support facilities also are available including standard specimen preparation facilities and an image analysis laboratory.

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Environmental Sample Preparation and Sequencing Facility

Argonne National Laboratory
9700 South Cass Avenue
Building 446, Rm. A176
Lemont, IL 60439
USA

Technical contact:
Sarah Owens
630-252-2101

http://www.bio.anl.gov/facilities/dna-sequencing-facility/

The Biosciences Division (BIO) Environmental Sample Preparation and Sequencing Facility (ESPSF) at Argonne National Lab is a state-of-the-art facility for nucleic acid extraction, library preparation, and ultra-high throughput sequencing. The core provides world class computation power, software, and expertise critical to the acquisition, analysis, and interpretation of next generation DNA sequence data. The core provides resources and services to ANL and UChicago, and to the broader scientific community (both US and abroad). The ESPSF team helps users determine the most efficient and cost effective approach to meet their research needs, including sequencing of metagenomic samples, both 16S and 18S rRNA amplicon sequencing for microbial community analysis, and ITS sequencing for fungal community analysis.

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Flow Cytometry Core at UChicago (UCFlow)

University of Chicago Flow Cytometry Facility
924 E. 57th St.
BSLC
Room R022
Chicago, IL 60637

Technical contact:
David Leclerc
773-702-5582

https://ucflow.uchicago.edu/

The University of Chicago Flow Cytometry Core facility is a shared research facility dedicated to the education and further advancement of flow cytometry technologies used in research and clinical studies at the University of Chicago. The facility staff is on hand to maintain the instrumentation, provide services of training, general education, and consultation.

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Genomics Facility

University of Chicago
Knapp Center for Biomedical Discovery
900 E. 57th St.
Room 1230C
Chicago, IL 60637

Technical contact:
Pieter W. Faber
773-834-8420

https://fgf.uchicago.edu/

The University of Chicago Genomic Facility offers Next-Gen (Sequencing and Library prep), Micro-array (Affymetrix / Illumina), Sanger DNA Sequencing, and Bio-analyzer sample QC services.

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Gnotobiotic Mouse Facility

Technical Contact:
Betty Theriault, DVM
Gnotobiotic Mouse Component co-Director
Phone: 773-702-9362

http://www.uchicagoddrcc.org/research-cores/host-microbe-core/gnotobioti...

The University of Chicago has a facility in which mice of many different genetic backgrounds are derived as germ-free, having no microbes on or inside of them. These gnotobiotic mice serve as research models that are key in identifying the genes responsible for so many of our disease predispositions and, more importantly, the mechanisms responsible so that we find ways to interfere with progression.

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Integrated Light Microscopy Core Facility

Abbott Memorial Hall
5812 S. Ellis Ave.
Room AB-129
Chicago, IL 60637
(Bindokas)

Knapp Center for Biomedical Discovery
900 E. 57th St.
Room 1250
Chicago, IL 60637
(Bond, Labno)

Technical contact:
Vytas Bindokas
773-702-4875

http://digital.bsd.uchicago.edu/index.php

The facility was established to provide state-of-the-art microscopy imaging stations that would otherwise be prohibitively expensive for individual laboratories to obtain on their own. Though we are not a service facility (i.e. we do not routinely perform experiments the users), we will provide assistance on the imaging aspects of the user's experiment. We have developed a strong and broad base of users and continue to train new users.

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Marine Resource Center

MRC 316
7 MBL Street
Woods Hole, MA 02543

Technical contact:
David Remsen
508-289-7477

http://www.mbl.edu/mrc/

The Marine Resources Center is a highly advanced facility for maintaining, culturing, and providing aquatic organisms essential to advanced biological, biomedical, and ecological research.

Service plays an important and complementary role in this 32,000 square-foot, state-of-the-art facility. The Marine Resources Department (MRD) and its life support systems and personnel have increased the ability of MBL scientists to conduct research and have inspired new concepts in scientific experiments.

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Mass Spectroscopy Facility

University of Chicago
Searle Chemistry Laboratory, 340C
5735 S. Ellis Ave.

Technical contact:
C. Jin Qin
773-834-8905

https://chemistry.uchicago.edu/page/facilities.html

The UChicago mass spec facility in the Chemistry Department routinely runs quantitative, accurate mass, and nominal mass studies of known small molecule metabolites, synthesized compounds by LC/GC-MS (and MS/MS), and standard comparisons. These studies are on the scale of 50-2,000 Da. Instruments include chromatography and mass spectrometers, IR, and ICP-MS.

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Nuclear Magnetic Resonance Facility

Nuclear Magnetic Resonance Facility
Department of Chemistry at The University of Chicago
5735 South Ellis Avenue, Chicago, IL 60637

Technical contact:
Antoni Jurkiewicz
773-834-7420

http://chem-nmr.uchicago.edu/

The NMR Facility serves the students, faculty, and staff across the departments of U of C and Argonne National laboratory, allowing users to obtain their own spectra. There are approximately 140 active user accounts in existence and about ~40,000 samples are run annually. In order to become a user of the NMR facility, one needs to be trained and tested prior to establishing an account. The facility user’s research adviser obtains the bill containing the fee for the time used.

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Pritzker Nanofabrication Facility

William Eckhardt Research Center (ERC)
5640 S. Ellis Ave., Lower Level 1
Chicago, IL 60637
773-834-3548

http://pnf.uchicago.edu/

Our mission is to translate advances in basic physics, chemistry, biology and computation into new tools to address important societal problems and, to create a research and teaching environment to enhance and transmit these capabilities from scientific generation to generation. The IME includes the Pritzker Nanofabrication Facility, an ISO Class 5 cleanroom that specializes in advanced lithographic processing of hard and soft materials.

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Proteomics Core Laboratory

Proteomics Core Laboratory
Cummings Life Science Center
920 East 58th Street, Chicago, IL 60637

Technical contact:
Don Wolfgeher
773-834-3379

https://proteomics.uchicago.edu/

The Proteomics Core Facility is a mass spectrometry facility dedicated to the characterization of proteins and peptides. This facility provides advice and services pertaining to peptide synthesis, protein sequencing, mass spectrometry, amino acid analysis, and more.

Basic User fees include all standard solvents (ie water, methanol, acetonitrile, isopropanol, but not deuterated solvents), columns (ie C4, C8, C18, other types may cost more), calibrants (for esi and maldi) and routine consumables (sample vials, filter vials, pipet tips etc.., but use of zip-tips or whatman filter vials may incur a charge if needed in excessive quantity, check the website for details).
Please inquire for unusual requirements.

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University of Chicago Digestive Disease Research Core Center (DDRCC)

The University of Chicago Digestive Diseases Research Core Center
University of Chicago Medical Center
900 #. 57th Street MB 9
Chicago, IL 60637
773-702-6458

Technical contact:
Joeli Brinkman
773-834-0832

http://www.uchicagoddrcc.org

The DDRCC is committed to building a better understanding of gastrointestinal diseases by fostering research, collaboration, and new technology and by providing education and resources to talented investigators in the field of digestive disease research. We offer state of the art services through five core facilities including the Integrated Translational Research Core, the Host-Microbe Core, the Administrative Core, the Tissue Engineering and Cell Models Core, and the Tissue and Cell Analysis Core.

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W. M. Keck Ecological and Evolutionary Genetics Facility

Technical contact:
Hilary Morrison
508-289-7339

http://www.mbl.edu/jbpc/keck/

The Keck Facility at the Josephine Bay Paul Center (JBPC) is equipped for high-throughput DNA template production, capillary sequencing, and “Next-Gen” library preparation and sequencing. We currently operate an Illumina MiSeq (2 x 300 PE reads; up to 20M clusters) and NextSeq (2 x 150 PE reads; up to 400M clusters). JBPC and other MBL laboratories have priority use of the facility, but it is available to “outside users” engaged in collaborative research with JBPC PIs, including those at the University of Chicago, on a cost-recovery basis. Please be aware that the Keck Facility is neither a core facility nor a commercial sequencing service. Instrument acquisition, maintenance, and personnel are supported primarily through JPBC PI grants Users are expected to complete the majority of sample preparation and to recognize the concept of shared risk.

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