Mark Mimee

The Mimee Lab leverages synthetic biology to engineer the microbiome, exploring strategies to modify commensal bacteria and bacteriophage for diagnostic and therapeutic applications.By genetically manipulating commensal microbes, we seek to create living devices that can serve as biosensors to probe the structure and function of the microbiome and as cell-based therapeutics for infectious and inflammatory disease. Additionally, we develop approaches to augment the natural properties of viruses that infect bacteria, called bacteriophage, to create novel therapies for antibiotic-resistant bacterial infections. Our long-term vision is to implement these synthetic biology technologies to chart new basic and translational studies to exploit the microbiota for human health.



https://voices.uchicago.edu/mimeelab/

Massachusetts Insitute of Technology
Cambridge, MA, USA
- Synthetic Biology
2019

Massachusetts Insitute of Technology
Cambridge, MA, USA
PhD - Microbiology
2018

McGill University
Montreal, QC, Canada
BSc - Microbiology & Immunology
2011

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis.
Yehl K, Lemire S, Yang AC, Ando H, Mimee M, Torres MT, de la Fuente-Nunez C, Lu TK. Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis. Cell. 2019 Oct 03; 179(2):459-469.e9.
PMID: 31585083

Cell-based biosensors for immunology, inflammation, and allergy.
Inda ME, Mimee M, Lu TK. Cell-based biosensors for immunology, inflammation, and allergy. J Allergy Clin Immunol. 2019 Sep; 144(3):645-647.
PMID: 31376406

An ingestible bacterial-electronic system to monitor gastrointestinal health.
Mimee M, Nadeau P, Hayward A, Carim S, Flanagan S, Jerger L, Collins J, McDonnell S, Swartwout R, Citorik RJ, Bulovic V, Langer R, Traverso G, Chandrakasan AP, Lu TK. An ingestible bacterial-electronic system to monitor gastrointestinal health. Science. 2018 05 25; 360(6391):915-918.
PMID: 29798884

Microbiome therapeutics - Advances and challenges.
Mimee M, Citorik RJ, Lu TK. Microbiome therapeutics - Advances and challenges. Adv Drug Deliv Rev. 2016 10 01; 105(Pt A):44-54.
PMID: 27158095

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota.
Mimee M, Tucker AC, Voigt CA, Lu TK. Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota. Cell Syst. 2016 Mar 23; 2(3):214.
PMID: 27135367

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Litchfield LM, Mukherjee A, Eckert MA, Johnson A, Mills KA, Pan S, Shridhar V, Lengyel E, Romero IL. Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer. Oncotarget. 2015 Sep 15; 6(27):23548-60.
PMID: 29798884

Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota.
Mimee M, Tucker AC, Voigt CA, Lu TK. Programming a Human Commensal Bacterium, Bacteroides thetaiotaomicron, to Sense and Respond to Stimuli in the Murine Gut Microbiota. Cell Syst. 2015 Jul 29; 1(1):62-71.
PMID: 26918244

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.
Citorik RJ, Mimee M, Lu TK. Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases. Nat Biotechnol. 2014 Nov; 32(11):1141-5.
PMID: 25240928

Bacteriophage-based synthetic biology for the study of infectious diseases.
Citorik RJ, Mimee M, Lu TK. Bacteriophage-based synthetic biology for the study of infectious diseases. Curr Opin Microbiol. 2014 Jun; 19:59-69.
PMID: 24997401

Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA.
Thanabalasuriar A, Bergeron J, Gillingham A, Mimee M, Thomassin JL, Strynadka N, Kim J, Gruenheid S. Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA. Cell Microbiol. 2012 Aug; 14(8):1206-18.
PMID: 22432415

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